Dr. Geoffrey F. StrouseProfessor
Ph.D (1993) University of North Carolina at Chapel Hill
Research InterestMATERIALS AT THE NANOSCALE
The Strouse group runs a highly collaborative, interdisciplinary team of scientists (inorganic, materials, analytical, physical, physics, engineering and biochemistry students), that utilize the tools of spectroscopy (time-resolved optical, vibrational, structural (XRD, XAS), NMR, magnetism, optical microscopy and electron microscopy) and the ability to selectively synthesize, interrogate, and manipulate materials at the nanoscale to ask questions that address a wide range of physical and biological questions.
The research effort takes todays discoveries to tommorrows devices by tareting the science and application of nanocrystals in four primary research areas:
(a)Sustainability: The use of modern microwave chemistry methods to prepare metal, semiconductor, and insulators at the nanoscale via sustainable high throughput techniques;
(b) Energy: Innovative nanomaterials for solid state lighting ((LEDs), spin electronics (spintronics, dilute magnetic semiconductors), and magnetic composites for advanced motor technology to reduce size, power demands, and improve performance;
(c) Optical Rulers: Development of optical based biophysical tools for temporal (picosecond), spatial (from 10's of nm to micron), and spectral(UV- NIR) elucidation of distances in biological structures from the isolated nucleic acid sequence to events within a cell; and
(d) Nano Bio-Medicine: Application and development of multi-modal nanomaterials to interrogate the chemistry of the brain with a focus on Stroke and TBI.
The synthetic design team focuses on the use of microwave chemistry for the development of synthetic methodologies for preparation of new quantum dot, metal and opical materials using industrially relevant synthetic methodologies. The use of the MW methods for nanomaterial production has been adapted by several industrial companies proving the chemistry you do today can impact society
We have extrapolated these strategies to develop new materials that can be chemically doped for application to our efforts in phosphor and lighting efforts, magnetic materials for applications in motor development, and as multi-modal optical/MRI (magnetic resonance imaging) contrast agents used in biomedical studies.
ENERGY (lighting and magnetism)
The sustainable lighting team addresses the development of LED based lighting technologies as a safer replacement technology of compact fluorescent lights. Through the development of quantum dot based phosphors and glass technology, replacement lighting based on solid state phosphors is a reality.
The magnetics team probes the close interplay among charge, spin, and lattice degrees of freedom in solid state materials at the nanoscale. Magnetic and optical studies on dilute magnetic semiconductors suggest enhancement of magnetic exchange between dopant ions in confined system, which arises from changes in the nature of coupling in size-restricted materials. Development of new magnetic composites are finding applications in new motor technologies.
OPTICAL RULERS (Biophysics)
Nanometal surface energy transfer (NSET) is a molecular ruler technique developed by our group that has been utilized to optically probe long distances in biomolecular structures. We investigate the time resolved experimental and theoretical properties of NSET to measure distances between 40 A and 200 A. The use of Molecular rulers for monitoring change in nucleic acid structures has provided exceptional insight into the conformational dynamics of nucleic acid structures. Extrapolation to in-vitro and in-vivo monitoring is allowing the dynamics of cellular transfection to be temporally, spatially, and spectrally analyzed using confocal microscopy. Further development is allowing chemical markers of disease states to be followed in-vitro in real time. Such methods are refining the toolbox of experimental methods available to the Bio-physical scientist.
NANO BIOMEDICAL (Multimodal probes for neuroscience)
Developing nanotechnology to transform a primary cell into a stable bio-reactor of a desirable protein for enhanced therapeutic effects to track and improve outcomes in brain injuries (TBI, stroke). This collaborative project with the College of Medicine and Bio-medical Engineering has developed nanoparticle-driven stem cell delivery systems that are versatile enough to permit us to reliably regulate the expression of a host of genes in a controlled and traceable fashion. The effort may be applied to a wide variety of pre-clinical disease models with the ultimately goal of clinical testing and application.
|Dai, QL (Dai, Qilin)1; Foley, ME (Foley, Megan E.)1; Breshike, CJ (Breshike, Christopher J.)1; Lita, A (Lita, Adrian)1; Strouse, GF (Strouse, Geoffrey F.)1 Ligand-Passivated Eu:Y(2)O(3) Nanocrystals as a Phosphor for White Light Emitting Diodes. : JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2011, Volume: 133 Issue: 39, 15475-15486|
|Zheng Weiwei; Strouse Geoffrey F. Involvement of Carriers in the Size-Dependent Magnetic Exchange for Mn:CdSe Quantum Dots. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2011, Volume: 133 Issue: 19, 7482-7489|
|Roberts, CW (Roberts, Colin W.)1; Hira, SM (Hira, Steven M.)2; Mason, BP (Mason, Brian P.)1; Strouse, GF (Strouse, Geoffrey F.)2; Stoltz, CA(Stoltz, Chad A.)1 Controlling RDX explosive crystallite morphology and inclusion content via simple ultrasonic agitation and solvent evaporation. CRYSTENGCOMM 2011, Volume: 13 Issue: 4, 1074-1076|
|Lita, A (Lita, Adrian)1; Washington, AL (Washington, Aaron L., II)1; van de Burgt, L (van de Burgt, Lambertus)1; Strouse, GF (Strouse, GeoffreyF.)1; Stiegman, AE (Stiegman, A. E.)1 Stable Efficient Solid-State White-Light-Emitting Phosphor with a High Scotopic/Photopic Ratio Fabricated from Fused CdSe-Silica Nanocomposites. ADVANCED MATERIALS 2010, Volume: 22 Issue: 36, 3987-3991|
|Rosenberg, JT (Rosenberg, Jens T.)1; Kogot, JM (Kogot, Joshua M.)2; Lovingood, DD (Lovingood, Derek D.)2; Strouse, GF (Strouse, GeoffreyF.)2; Grant, SC (Grant, Samuel C.)1 Intracellular Bimodal Nanoparticles Based on Quantum Dots for High-Field MRI at 21.1 T. MAGNETIC RESONANCE IN MEDICINE 2010, Volume: 64 Issue: 3, 871-882|