In short, we study chemical structure and reactivity trying to understand what organic molecules are and what they are capable of. Most of our research is hypothesis-driven and aims to discover new transformations of organic molecules. Reactions previously discovered in our lab have been applied for efficient light-activated cleavage of double-stranded DNA in cancer cells, sequence selective modification of single-stranded oligonucleotides, preparation of complex polycyclic structures related to carbon nanotubes and design of hybrid organic-inorganic materials.
Although the art of making organic molecules plays important role in our projects, the real fun starts once the molecules are made and one's ability to design a system which performs better than Nature is subjected to a critical test! These tests integrate learning and discovery in order to provide students with training for their future careers in organic, physical, analytical and biochemistry both in industry and in academia.
Gold B, Shevchenko NE, Bonus N, Dudley GB, Alabugin IV. Selective transition state stabilization via hyperconjugative and conjugative assistance: stereoelectronic concept for copper-free click chemistry. J Org Chem.2011, Nov 11. [Epub ahead of print]
Yang WY, Roy S, Phrathep B, Rengert Z, Kenworthy R, Zorio DA, Alabugin IV. Engineering pH-Gated Transitions for Selective and Efficient Double Strand DNA Photocleavage in Hypoxic Tumors. J Med Chem.2011, Nov 3. [Epub ahead of print]
Gilmore K, Alabugin IV. Cyclizations of Alkynes: Revisiting Baldwin\'s Rules for Ring Closure. Chem Rev.2011, Nov 9;111(11), 6513-56
Alabugin, I. Gilmore, K.; Manoharan, M. Rules for Anionic and Radical Ring Closure of Alkynes. J. Am. Chem. Soc. 2011, 133, 12608-12623
Baroudi, A.; Alicea, J.; Flack, P.; Kirincich, J.; Alabugin, I. V. Radical O→C Transposition: a Metal-Free Process for Conversion of Phenols into Benzoates and Benzamides. J. Org. Chem.2011, 76, 1521-37