Dr. Tyler McQuadeAssociate Professor
BS Chemistry UC - Irvine 1993 BS Biology UC - Irvine 1993 PhD Chemistry UW - Madison 1998 NIH Post-doctoral Fellow 1998-2001
Research InterestThe McQuade Group's overarching goal is to synthesize important molecules (biologically active for example)using efficient chemical methods and technology.
An overview of recently completed projects include:
Developing asymmetric copper(I)-based catalysts for synthesis of complex polyols:
Developing Novel Chemistry Using Microreactors:
Projects that we are working on now will leverage past accomplishments to produce compounds of significant importance. We are currently developing an ultra-efficient synthesis of the anti-viral drug nevirapine. If we are successful, millions of lives might be positively impacted.
|Opalka, SM (Opalka, Suzanne M.)2; Steinbacher, JL (Steinbacher, Jeremy L.)2; Lambiris, BA (Lambiris, Brandon A.)1; McQuade, DT (McQuade, D. Tyler)1 Thiourea/Proline Derivative-Catalyzed Synthesis of Tetrahydrofuran Derivatives: A Mechanistic View. JOURNAL OF ORGANIC CHEMISTRY 2011, Volume: 76 Issue: 16, 6503-6517|
|Park, JK (Park, Jin Kyoon)1; Lackey, HH (Lackey, Hershel H.)1; Ondrusek, BA (Ondrusek, Brian A.)1; McQuade, DT (McQuade, D. Tyler)1 Stereoconvergent Synthesis of Chiral Allylboronates from an E/Z Mixture of Allylic Aryl Ethers Using a 6-NHC-Cu(I) Catalyst. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2011, Volume: 133 Issue: 8, 2410-2413|
|Park, JK (Park, Jin Kyoon)1; Lackey, HH (Lackey, Hershel H.)1; Rexford, MD (Rexford, Matthew D.)1; Kovnir, K (Kovnir, Kirill)1; Shatruk, M(Shatruk, Michael)1; McQuade, DT (McQuade, D. Tyler)1 A Chiral 6-Membered N-Heterocyclic Carbene Copper(I) Complex That Induces High Stereoselectivity. ORGANIC LETTERS 2010, Volume: 12 Issue: 21, 5008-5011|
|Bogdan, A (Bogdan, Andrew)2; McQuade, DT (McQuade, D. Tyler)1 A biphasic oxidation of alcohols to aldehydes and ketones using a simplified packed-bed microreactor. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 2009, Volume: 5 Article Number: 17|
|Mason, BP (Mason, Brian P.); Hira, SM (Hira, Steven M.); Strouse, GF (Strouse, Geoffrey F.); McQuade, DT (McQuade, D. Tyler)1 Microcapsules with Three Orthogonal Reactive Sites. ORGANIC LETTERS 2009, Volume: 11 Issue: 7, 1479-1482|