Overview: Our fundamental research goal is to devise, develop, and apply new ideas in organic chemistry to the efficient synthesis of interesting molecules, particularly natural products with medicinal applications. Natural products research impacts the development of many important drugs; relevant examples include aspirin, penicillin, cortisone, and paclitaxel. Complex natural products arise from millions of years of evolutionary screening, and often target specific interactions in intricate biological systems. In these and many other cases, organic synthesis plays a key role in helping us capitalize on desired biological activities. We can continue to benefit from this natural selection process by developing practical syntheses of natural products and analogs. Download a statement on the research philosophy of the Dudley Lab View a recent research presentation by Professor Dudley This video seminar is best viewed on PC-based computers. A split screen provides a synchronized broadcast of a lecture and slide show. The one-hour presentation begins with a 2-3 minute introduction by Professor Igor Alabugin. Choice of Research Projects Two main criteria guide our choice of research topics in synthetic organic chemistry: 1. Will our efforts generate new knowledge in synthetic chemistry of interest to ourselves and to the greater chemistry community? 2. Will our efforts provide better access to synthetic compounds of interest to ourselves and to the greater science community? In the News, 2005: Work on cancer-killing compound nets FSU professor major grant In the News, 2007: New reagent delivers a chemical breakthrough at FSU [ Download the ChemFiles issue featuring the new benzylating reagent] [ Order a bottle of benzyloxypyridinium triflate from Sigma-Aldrich] Representative Publications [13] Kamijo, S.; Dudley, G. B. Tandem Nucleophilic Addition/Fragmentation Reactions and Synthetic Versatility of Vinylogous Acyl Triflates. J. Am. Chem. Soc. 2006, 128, 6499-6507. [15] Engel, D. A.; Dudley, G. B. Olefination of Ketones Using A Gold(III)-Catalyzed Meyer-Schuster Rearrangement. Org. Lett. 2006, 8, 4027-4029. [18] Poon, K. W. C.; Albiniak, P. A.; Dudley, G. B. Protection of alcohols using 2-benzyloxy-1-methylpyridinium trifluoromethanesulfonate: methyl (R)-(-)-3-benzyloxy-2-methyl propanoate. Org. Synth. 2007, 84, 295-305. [19] Dudley, G. B.; Engel, D. A.; Lam, H.; Poon, K. W. C.; Singletary, J. A. Synthesis of dihydro-epi-deoxyarteannuin B. Org. Lett. 2007, 9, 2839-2842. For a complete list of publications and other professional activities: Download Professor Dudley's CV in pdf-format... ...or, click on the "Publications" button under "Research" on the navigation pane for a list with hyperlinks to all independent research publications from the Dudley Lab.