News
The 2024 Bleiholder Spring Workshop is highlighted in an article by FSU College of Arts and Sciences
https://artsandsciences.fsu.edu/article/bleiholder-lab-hosts-annual-workshop-highlight-experimental-and-computational-methods.
Welcome to the Bleiholder Lab at Florida State University!
The Bleiholder Lab is currently accepting motivated graduate and undergraduate students from all fields of chemistry, biochemistry, and biophysics.
The Bleiholder Lab is currently accepting motivated graduate and undergraduate students from all fields of chemistry, biochemistry, and biophysics. Our research focuses on the development of experimental ion mobility spectrometry/mass spectrometry methods, computational/theoretical approaches, and the applications of IMS/MS in health-related biological systems. For more information, please contact bleiholder@chem.fsu.edu.
Instrumentation
In collaboration with Bruker Corporation, we develop tandem-trapped ion mobility spectrometry/mass spectrometry (tandem-TIMS/MS) as a novel analytical method to study complex, heterogeneous biological molecules. Currently our lab has two tandem-TIMS/MS instruments with different configurations and various ion activation methods.
Theory
Our lab develops theoretical approaches to elucidate detailed quaternary, tertiary, and primary structures of proteins from ion mobility/mass spectrometry data. Two computational methods have been published and patented: LCPA (Local Collision Probability Approximation) and SRA (Structure Relaxation Approximation).
Applications
We apply our experimental and theoretical approaches to investigate structure-function relationship of health-related, complex biological materials such as glycoprotein complexes, chemokines, and carbohydrates. We are especially interested in studying the glycan shield of viral spike proteins such as env of HIV or S of SARS-CoV-2.
Please check out our research tab for more information.
2023 Summer School
FSU Faculty Interview – Dr. Christian Bleiholder
Check out this video for a description of some of our work.