Department Web-Page

Dr. Hedi Mattoussi

Dr. Hedi Mattoussi

Distinguished Research Professor


  • Habilitation to Direct Research, Physical Chemistry/Nanomaterials, February 1994
  • Ph.D. Physical Chemistry, October 1987; Work done at the Collège de France, Condensed Matter Physics Laboratory.
  • M. S. Condensed Matter Physics, June 1984.
  • B. S. Physics, June 1982; graduated with Honors.

Contact Information
4006 CSL 850.645.8615
4702 CSL 850.645.9408
Programs of Research
Research Website
Research Specialities
Chemistry of Materials, Nanoscience, Photochemistry, Spectroscopy and Dynamics, Synthesis and Catalysis
1 Graduate; 2 Postdoc; 2 Visiting

Research Interest

Hedi Mattoussi Laboratory Page

Research areas: We focus on understanding, controlling and tailoring the interfaces between inorganic nanocrystals and biological (as well as non-biological) systems.  This requires making progress on few parallel tracks, including: nanoparticle design, structural and optical characterization, ligand design and characterization, chemical interfacing of QDs, Au nanoparticles and magnetic nanocrystals with biological systems, biosensing assemblies, in vivo imaging and sensing.

Research tools: synthetic organic and inorganic chemistry; 1H NMR; X-ray and light scattering techniques; TEM and SEM; Optical spectroscopy; energy transfer (FRET); FT-IR; Cell growth; Cell imaging.

Area 1: Design, synthesis and characterization of inorganic nanocrystals

Area 2: Design, synthesis and characterization of multidentate and multifunctional ligands

Area 3: Design of nanoparticle-bioconjugates as analytical tools for sensing, imaging and diagnostics


A. Kapur, S. Medina, W. Wang, G. Palui, X. Ji, J.P. Schneider, and H. Mattoussi “Enhanced Intracellular Delivery of Luminescent Quantum Dots Mediated by a Membrane-Active Peptide,” ACS Omega 2018, 3, 17164−17172. DOI: 10.1021/acsomega.8b02918
B. Zeng G. Palui, N. Zhan, C. Zhang, W. Wang, X. Ji, B. Chen, and H. Mattoussi, “Characterization of the Ligand Capping of Hydrophobic CdSe-ZnS Quantum Dots using NMR Spectroscopy,” Chem. Mater. 2018, 30, 225−238. DOI: 10.1021/acs.chemmater.7b04204
C. Zhang, G. Palui, B. Zeng, N. Zhan, B. Chen and H. Mattoussi, “Non-invasive Characterization of the Organic Coating of Biocompatible Quantum Dots using NMR Spectroscopy,” Chem. Mater. 2018, 30, 3454−3466. DOI: 10.1021/acs.chemmater.8b01033
M. Shi, K.L. de Mesy-Bentley, G. Palui, H. Mattoussi, A. Elder, H. Yang, “The roles of surface chemistry, dissolution rate, and delivered dose in the cytotoxicity of copper nanoparticles,” Nanoscale 2017, 9, 4739–4750. DOI: 10.1039/C6NR09102D
A. Kapur, F. Aldeek, X. Ji, M. Safi, W. Wang, A. Del Cid, O. Steinbock and H. Mattoussi, “Self-assembled Gold Nanoparticle-Fluorescent Protein Conjugates as Platforms for Sensing Thiol Compounds via Modulation of Energy Transfer Quenching,” Bioconjugate Chem. 2017, 28, 678–687. DOI: 10.1021/acs.bioconjchem.7b00006
N. Zhan, G. Palui, J-P. Merkl and H. Mattoussi, “Bio-orthogonal Coupling as a Means of Quantifying the Ligand Density on Hydrophilic Quantum Dots,” J. Am. Chem. Soc. 2016, 138, 3190−3201. DOI: 10.1021/jacs.5b13574
X. Ji, W. Wang, and H. Mattoussi, “Controlling the Spectroscopic Properties of Quantum Dots via Energy Transfer and Charge Transfer Interactions: Concepts and Applications,” Nano Today 2016, 11, 98—121. DOI: 10.1016/j.nantod.2015.09.004
N. Zhan, G. Palui, A. Kapur, V. Palomo, P.E. Dawson, and H. Mattoussi, “Controlling the Architecture, Coordination and Reactivity of Nanoparticle Coating Utilizing an Aminoacid Central Scaffold,” J. Am. Chem. Soc. 2015, 137, 16084−16097. DOI: DOI: 10.1021/jacs.5b10359