Chapter 20

TCA Cycle

Bridging Reaction:
Pyruvate ģ Acetyl-CoA

Pyruvate Dehydrogenase

Pyruvate Dehydrogenase, conít.

Pyruvate Dehydrogenase, conít.

ABCís of the TCA Cycle

Citrate Synthase


Fluoroacetate Inhibition

Isocitrate Dehydrogenase

Isocitrate Dehydrogenase

a-Ketoglutarate Dehydrogenase

Succinyl-CoA Synthetase

Succinate Dehydrogenase

Succinate Dehydrogenase, conít.

Fumarase and Malate Dehydrogenase

Tracing Carbon Atoms

TCA Cycle as an Amphibolic Pathway

Anaplerotic Reactions

Pyruvate Carboxylase

Net degradation of TCA intermediates

Regulation of TCA Cycle

Regulation of Pyruvate Dehydrogenase

Regulation of Citrate Synthase

Regulation of Isocitrate Dehydrogenase

Regulation of a-Ketoglutarate Dehydrogenase

Glyoxalate Cycle

Glyoxalate Cycle, conít.