Pyruvate Dehydrogenase
Multienzyme complex (See Figure p.646)
Multiple copies of three enzymes, each with
a prosthetic group:
Pyruvate
Dehydrogenase
PDH
Thiamine
Pyrophosphate
24 dimers
Dihydrolipoyl
Transacetylase
TA
Lipoic Acid
24 subunits
(cubic core)
Dihydrolipoyl
Dehydrogenase
DLD
FAD
12 subunits