Isocitrate Dehydrogenase
First oxidative step of the cycle.
First CO2 produced.
Mechanism similar to other beta-hydroxyacid
oxidative decarboxylations:
Malic enzyme
6-phosphogluconate dehydrogenase
An isozyme of isocitrate dehydrogenase in both
mitochondria and cytoplasm utilizes NADP+ to
form NADPH.