a-Ketoglutarate Dehydrogenase
The second oxidative step of the TCA cycle.
Oxidative decarboxylation of an alpha-keto acid.
(Figure 20.11)
Mechanism identical to that of pyruvate
dehydrogenase.
NAD+ and CoASH cosubstrate coenzymes
TPP, lipoic acid, and FAD prosthetic group coenzymes.
Reaction is removed from equlibrium.