Regulation of Pyruvate
Dehydrogenase
TA inhibited by acetyl-CoA, activated by CoASH
DLD inhibited by NADH, activated by NAD+
Mammalian enzyme inhibited by phosphorylation
with PDH kinase (Figure 20.27)
PDH kinase activated by NADH and acetyl-CoA
PDH phosphatase activated by Ca2+
AMP activates, GTP inhibits