FLORIDA STATE / PEOPLE / FACULTY
Dr. Scott Stagg, Professor
B.S. Oglethorpe University (1996)
Ph.D. University of Alabama at Birmingham (2002)
Postdoc, Georgia Institute of Technology (2002-2003)
Postdoc, The Scripps Research Institute (2003-2007)
Programs of Research
Structural Biology, Bioanalytical, Chemical Biology
The Stagg research group has two research foci: 1) determining the structural mechanisms that facilitate vesicle trafficking in cells, and 2) methods for high-throughput high-resolution cryo-EM. On the vesicle trafficking side, we determine the structures of protein and membrane complexes such as COPII and clathrin that control vesicle trafficking in eukaryotic cells. On the cryo-EM methods side, we create tools to make cryo-EM faster and more reproducible. This includes creating new techniques for specimen preparation and writing software for automation of data collection and processing.
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Mendez, J.H.; Mehrani, A.; Randolph, P.; Stagg, S. Throughput and resolution with a next-generation direct electron detector. IUCrJ. 2019, 6, 1007-1013.
Meyer, N.L.; Hu, G.; Davulcu, O.; Xie, Q.; Noble, A.J.; Yoshioka, C.; Gingerich, D.S.; Trzynka, A.; David, L.; Stagg, S.M.; Chapman MS. Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR. eLife. 2019, 8, e44707.
Paraan, M.; Bhattacharya, N.; Uversky, V.N.; Stagg, S.M.; Flexibility of the Sec13/31 cage is influenced by the Sec31 C-terminal disordered domain. J. Struct. Biol. 2018, 204, 250-260.
Noble, A.J.; Stagg, S.M. Automated batch fiducial-less tilt-series alignment in Appion using Protomo. J. Struct. Biol. 2015, 192, 270-8.
Noble, A.J.; Zhang, Q.; O’Donnell, J.; Hariri, H.; Bhattacharya, N.; Marshall, A.G.; Stagg, S.M. A pseudoatomic model of the COPII cage obtained from cryo-electron microscopy and mass spectrometry. Nat. Struct. Mol. Biol. 2013, 20, 167-73.