Biochemistry Symposium

Biochemistry & Biophysics Symposium
Dr. Rajeev Prabhakar, Organizer

Friday May 18th Biochemistry & Biophysics I Presentations

Time	Location	Presenter	Abstract Title
8:55AM-9:00AM	Edinburgh X	Rajeev Prabhakar	INTRODUCTION
9:00AM - 9:25AM	Edinburgh X	Jingdong Ye	A NEW MODEL OF GLYCINE RIBOSWITCH FOLDING
9:25AM - 9:50AM	Edinburgh X	Gail Fanucci	ELUCIDATING THE RELATIONSHIP BETWEEN CONFORMATIONAL SAMPLING AND DRUG RESISTANCE IN HIV-1 PR
9:50AM - 10:15AM	Edinburgh X	Randy Larsen	PHOTOACOUSTIC CALORIMETRY STUDIES OF CO PHOTORELEASE FROM SOL-GEL ENCAPSULATED HORSE HEART MYOGLOBIN
10:15AM - 10:35AM	Edinburgh X	Namrata Singh	NIF-EN PROTEIN: ROLE AS A MOLYBDATE REDUCTASE IN THE BIOSYNTHESIS OF THE NITROGENASE IRON-MOLYBDENUM COFACTOR
10:35AM -11:00AM	Edinburgh Foyer	MID-MORNING BREAK
11:00AM - 11:25AM	Edinburgh X	Roger Leblanc	GRAPHENE OXIDE AS AN EFFICIENT QUENCHER FOR THE FLUORESCENCE OF AMINO ACIDS, PEPTIDES, AND PROTEINS
11:25AM - 11:50AM	Edinburgh X	Igor Lednev	SPONTANIOUS REFOLDING OF AMYLOID FIBRILS
11:50AM - 12:10PM	Edinburgh X	Anant Paravastu	A SOLID STATE NMR CONSTRAINED STRUCTURAL MODEL FOR THE RADA16-I DESIGNER SELF-ASSEMBLING PEPTIDE

Friday May 18th Biochemistry & Biophysics II Presentations

Time	Location	Presenter	Abstract Title
1:30PM - 1:55PM	Edinburgh X	Jamie Walls	IMPROVING RESOLUTION IN NMR USING PATHWAY SELECTIVE PULSES
1:55PM - 2:20PM	Edinburgh X	Qing-Xiang Amy Sang	PHOSPHOPROTEINS AND SIGNAL PATHWAYS OF HUMAN PROSTATE CANCER AND TRIPLE-NEGATIVE BREAST CANCER
2:20PM - 2:45PM	Edinburgh X	David Rodgers	MECHANISM FOR BROAD SPECIFICITY IN NEUROPEPTIDASES
2:45PM - 3:05PM	Edinburgh X	Mehmet Ozbil	INVESTIGATING THE ACTIVATION OF INSULIN DEGRADING ENZYME (IDE) AND SELECTIVITY OF NEPRILYSIN (NEP)
3:05PM - 3:30PM	Edinburgh Foyer	MID-AFTERNOON BREAK
3:30PM - 3:55PM	Edinburgh X	Giovanni Gadda	DETOXIFICATION OF THE METABOLIC TOXIN PROPIONATE-3-NITRONATE BY FUNGAL NITRONATE MONOOXYGENASE
3:55PM - 4:20PM	Edinburgh X	Wei Yang	SAMPLING FOR DYNAMIC-STRING ENZYME REACTION SIMULATIONS: AN IMPROVE ON-THE-PATH RANDOM WALK METHOD
4:20PM - 4:40PM	Edinburgh X	Donald Hamelberg	PROBING FUNCTIONAL DYNAMICS IN ENZYMES USING SIMULATIONS
4:40PM - 5:05PM	Edinburgh X	Arjan van der Vaart	IMPORTANCE OF DOMAIN CLOSURE FOR THE AUTOACTIVATION OF ERK2

Saturday May 19th Biochemistry & Biophysics III Presentations

Time	Location	Presenter	Abstract Title
9:00AM - 9:25AM	Edinburgh V-VI	Adrian Roitberg	THEORETICAL STUDIES OF TRYPANOSOMA CRUZI’s TRANSIALIDASE
9:25AM - 9:50AM	Edinburgh V-VI	Henry L Woodcock	UNLOCKING THE BINDING AND REACTION MECHANISM OF HYDROXYUREA SUBSTRATES AS BIOLOGICAL NITRIC OXIDE DONORS
9:50AM - 10:10AM	Edinburgh V-VI	Dhruv Chakravorty	UNRAVELING THE STRUCTURE FUNCTION AND DYNAMICS OF ARSR/SMTB TRASCRIPTIONAL REPRESSORS
10:10AM - 10:35AM	Edinburgh V-VI	Huan-Xiang Zhou	PREDICTION AND DISSECTION OF WIDELY-VARYING ASSOCIATION RATE CONSTANTS OF ACTIN-BINDING PROTEINS
10:35AM -11:00AM	Edinburgh Foyer	MID-MORNING BREAK
11:00AM - 11:25AM	Edinburgh V-VI	Otto Phanstiel	DEVELOPMENT OF HYPERSELECTIVE POLYAMINE TRANSPORT LIGANDS AND SELECTIVITY AGAINST SPECIFIC HUMAN CANCERS
11:25AM - 11:50AM	Edinburgh V-VI	Kathryn Grant	A NEW TREATMENT APPROACH TO LYSOSOMAL STORAGE DISEASE: EXPLORING POTENTIAL BIOMEDICAL APPLICATIONS OF SIMPLE METAL ION SALTS
11:50AM - 12:10PM	Edinburgh V-VI	Alaa Hashim	PROBING THE ROLE OF (BIS)PHOSPHATE IN INHIBITORS TOWARD CuII-AMYLOID?-INDUCED OXIDATIVE STRESS IN ALZHEIMER’S DISEASE: KINETICS AND NMR RELAXATION STUDIES

Saturday May 19th Biochemistry & Biophysics IV Presentations

Time	Location	Presenter	Abstract Title
1:30PM-1:55PM	Edinburgh V-VI	Patrick Charbonneau	PROTEIN CRYSTALLIZATION: CAN SPHERICAL COWS HELP?
1:55PM - 2:20PM	Edinburgh V-VI	Robert Y. Igarashi	REGULATION OF THE ATPASE ACTIVITY OF ABCE1 FROM PYROCOCCUS ABYSSI BY Fe-S CLUSTER STATUS AND Mg2+: IMPLICATION FOR RIBOSOMAL FUNCTION
2:20PM - 2:45PM	Edinburgh V-VI	Alex Angerhofer	THE ENZYMATIC MECHANISM OF OXALATE DECARBOXYLASE INVESTIGATED BY EPR AND ENDOR
2:45PM - 3:05PM	Edinburgh V-VI	Kersten Schroeder	FOLDING OF THE KINK-TURN RNA MOTIF
3:00PM - 3:30PM	Edinburgh Foyer	MID-AFTERNOON BREAK
3:30PM - 3:50PM	Edinburgh V-VI	Beatrice Kallifatidis	IDENTIFICATION OF HALLUCINOGENIC AND TOXIC FUNGI BY RANDOM AMPLIFIED MICROSATELLITES (RAMS)
3:50PM - 4:10PM	Edinburgh V-VI	Sumit Handa	1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE (DXS) AS A TARGET FOR ANTIMALARIAL DRUGS
4:10PM - 4:30PM	Edinburgh V-VI	Albaro L. Perez	CHRONIC TOXICITY SCREENING ASSAY (USING LUMINESCENT VIBRIO FISCHERI) FOR THE INSECTICIDE DIBROM IS ~20X MORE SENSITIVE THAN AN ACUTE ASSAY; WE NOTED AN EC50 OF 0.68 PPM FOR DIBROM
4:30PM - 4:50PM	Edinburgh V-VI	Valeria Valbuena	PURIFICATION AND CHARACTERIZATION OF GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE FROM CAENORHABDITIS ELEGANS