Faculty

FLORIDA STATE   /   PEOPLE   /   FACULTY

Michael Blaber Ph.D., Professor
BA (1980) University of California at Santa Barbara
Ph.D. (1990)University of California at Irvine

Michael Blaber Ph.D.

Contact Information

Email michael.blaber@med.fsu.edu
Office Main Campus (850) 644-3361

Job Description

Research, Teaching and Service
A complete Curriculum Vitae can be found here

research specialties

Protein structure, stability and folding; Protein design of human fibroblast growth factor-1 for therapeutic application; Protein evolution

BioSketch

Dr. Blaber graduated with a B.A. in Biochemistry/Molecular Biology from the University of California at Santa Barbara in 1980. At the time, molecular biology was a new field, and UCSB was one of the few institutions that offered an undergraduate degree in this area. After graduation, Blaber was recruited by Genentech Inc. as a Research Assistant in Protein Chemistry. Genentech was one of the first biotech companies, and Blaber was the 120th employee. After five exciting years studying the properties of recombinant human proteins, Blaber left Genentech and entered the Ph.D. program in the Department of Biological Sciences in the College of Medicine at UC Irvine (in the laboratory of Dr. Ralph A. Bradshaw). During this time Blaber studied structure/function relationships of serine protease proteins, and was supported by an undergraduate NIH fellowship and an Earl C. Anthony dissertation fellowship. After graduating, Blaber was a Postdoctoral Fellow in the laboratory of Dr. Brian Matthews, Howard Hughes Medical Institute, University of Oregon where he was supported by an NIH Postdoctoral Fellowship to study protein structure and stability relationships. Upon completing his Postdoctoral work, Blaber joined the Department of Chemistry at FSU as an Assistant Professor, receiving a University Teaching Award in 1999 for undergraduate chemistry instruction. Blaber subsequently earned tenure in the FSU College of Arts and Sciences, and promotion to Associate Professor in 2000. In fall 2005 he joined the Department of Biomedical Sciences in the FSU College of Medicine. In 2006 he was tenured in the FSU College of Medicine, and in 2007 he was promoted to Professor, and also received the 2007 Outstanding Senior Faculty Researcher Award. In 2009 Blaber received the E.K. Frey/E. Werle Gold Medal for research in the area of Kallikrein-related peptidases. Blaber was awarded the 2013 Outstanding Senior Faculty Researcher Award. To date, 18 patents related to Blaber’s research have been awarded or are pending. Intellectual property derived from his research at FSU has been licensed to Trefoil Therapeutics Inc. and Lomir Biomedical Inc. A total of 8 Postdoctoral Fellows, 20 Graduate Students, 2 Medical Students, and 69 Undergraduate Students have been trained in his laboratory.

Honors / Awards

Publications
Awards:
Outstanding Senior Faculty Researcher Award, Department of Biomedical Sciences, FSU (2013)

E.K. Frey/E. Werle Gold Medal, FSU 2009

Outstanding Senior Faculty Researcher Award, Department of Biomedical Sciences, FSU (2007)

Faculty Ranking #1, Department of Chemistry & Biochemistry, FSU (2002)

University Teaching Award, FSU (1999)
First Year Assistant Professor Award, FSU (1995)

N.I.H. Postdoctoral Fellowship GM13709-01, Institute of Molecular Biology, University of Oregon, Eugene OR (3/90-2/93)
N.I.H. Predoctoral Fellowship GM07134-11, University of California, Irvine CA (9/86-8/89)
Earl C. Anthony Dissertation Fellowship, University of California, Irvine CA (9/89-12/89)
Patents:
17 US patents, 1 European patent (issued/pending)

Publications

Publications
Folding Nucleus Structure Persists in Thermally-aggregated FGF-1, but a Symmetric Mutant sharing the Folding Nucleus does not Aggregate, Longo, L.M., Gao, Y., Tenorio, C.A., Wang, G., Paravastu, A.K. and Blaber, M. (2017 DOI: 10.1002/pro.3332 Epub ahead of print)
An S116R Phosphorylation Site Mutation in Human FGF-1 Differentially Affects Mitogenic and Glucose Lowering Activities, Xia, X., Kumru, O.S., Blaber, S.I., Middaugh, C.R., Li, L., Ornitz, D.M., Suh, J.M., Atkins, A.R., Downes, M., Evans, R.M., Tenorio, C.A., Bienkiewicz, E. and Blaber, M., J. Pharm. Sci. 105, 3507-19 (2016)
An S116R Phosphorylation Site Mutation in Human FGF-1 Differentially Affects Mitogenic and Glucose Lowering Activities, Xia, X., Kumru, O.S., Blaber, S.I., Middaugh, C.R., Li, L., Ornitz, D.M., Suh, J.M., Atkins, A.R., Downes, M., Evans, R.M., Tenorio, C.A., Bienkiewicz, E. and Blaber, M., J. Pharm. Sci. 105, 3507-19 (2016)
Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for “2nd Generation” Therapeutic Application, Xia, X., Kumru, O.S., Blaber, S.I., Middaugh, C.R., Li, L., Ornitz, D.M., Sutherland, M.A., Tenorio, C. and Blaber, M., J. Pharm. Sci. 105, 1444-53 (2016)
Evolution of a Protein Folding Nucleus, Xia, X., Longo, L.M., Sutherland, M.A. and Blaber, M., Protein Science 25, 1227-40 (2016) “Protein Evolution and Design” special issue
Accelerated Healing in NONcNZO10/LtJ Type 2 Diabetic Mice by FGF 1, Blaber, S.I., Diaz, J. and Blaber, M., Wound Repair and Regeneration 23, 538-49 (2015)