Faculty
FLORIDA STATE / PEOPLE / FACULTY
Dr. Lei Zhu, Professor
Professional Preparation/Appointments
Ph.D. New York University (2003)
Contact Information
| lzhu@chem.fsu.edu | ||
| Office | 716 DLC | 850.645.6813 |
| Lab | 755 DLC | |
Programs of Research
Materials, Organic
Research Specialties
Bioanalytical, Chemical Biology, Synthesis and Catalysis, Spectroscopy and Photochemistry
Research Interest
The Zhu group is interested in solving fundamental problems in chemistry and developing new technologies using the tools in supramolecular chemistry – the chemistry mediated by rapidly equilibrating reactions. Metal coordination is one example of “rapidly equilibrating reactions” that we have invested much effort in studying. The acquired fundamental knowledge from out work aids the progress in other areas, including the development of fluorescent sensing technologies and new catalytic processes. Three current research topics are 1) developing fluorescent indicators for imaging biological Zn(II) ions, 2) photophysical investigation of interesting fluorescent molecules, and 3) developing copper-merdiated coupling reactions based on mechanistic hypotheses.
Publications
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| Meisner, Q. J.; Younes, A. H.; Yuan, Z.; Sreenath, K.; Hurley, J. J. M.; Zhu, L. Excitation-Dependent Multiple Fluorescence of a Substituted 2-(2′-Hydroxyphenyl)benzoxazole. J. Phys. Chem. A. 2018, 122, 9209-9223. |
| Macias-Contreras, M.; He, H.; Zhu, L. Beyond O6-benzylguanine: O6-(5-pyridylmethyl)guanine as a Substrate for the Self-labeling Enzyme SNAP-tag. Bioconjugate Chem. 2018, 29, 4104-4109. |
| Brassard, C. J.; Zhang, X.; Brewer, C. R.; Liu, P.; Clark, R. J.; Zhu, L. Cu(II)-Catalyzed Oxidative Formation of 5,5’-Bistriazoles. J. Org. Chem. 2016, 81, 12091–12105. |
| Sreenath, K.; Yuan, Z.; Allen, J. R.; Davidson, M. W.; Zhu, L. A Fluorescent Indicator for Imaging Lysosomal Zinc(II) with FRET-Enhanced Photostability and A Narrow Band of Emission. Chem. Eur. J. 2015, 21, 867-874. |
| Kuang, G.-C.; Guha, P. M.; Brotherton, W. S.; Simmons, J. T.; Stankee, L. A.; Nguyen, B. T.; Clark, R. J.; Zhu, L. Experimental Investigation on the Mechanism of Chelation-Assisted, Copper(II) Acetate-Accelerated Azide-Alkyne Cycloaddition. J. Am. Chem. Soc. 2011, 133, 13984-14001. |