FLORIDA STATE / PEOPLE / FACULTY
Dr. Brian G. Miller, Professor
B.S. Truman State University (1996)
Ph.D. University of North Carolina at Chapel Hill (2001)
Postdoc, University of Wisconsin (2001-2005)
Programs of Research
Chemical Biology, Structural Biology, Synthesis and Catalysis
The Miller research group is interested in understanding the mechanisms of enzyme action and how their dysfunction leads to human disease. We are also interested in resurrecting extinct enzymes to understand the evolutionary processes responsible for the biophysical features of extant catalysts. Members of the Miller group utilize a range of techniques from the fields of biochemistry, evolutionary biology, biophysics, organic chemistry and microbial genetics.
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Sternisha, SM, Miller BG Molecular and cellular regulation of human glucokinase. Arch. Biochem. Biophys. 2019, 663, 199-213.
Paukovich et al. Biliverdin reductase B dynamics are coupled to coenzyme binding. J. Mol. Biol. 2018, 430, 3234-3250.
Mailyan, AK, Chen, JL, Li, W, Keller, AA, Sternisha, SM, Miller, BG, Zakarian, A Short total synthesis of 15N5-cylindrospermopsins from 15NH4Cl enables precise quantification of freshwater cyanobacterial contamination. J. Am. Chem. Soc. 2018, 140, 6027-6032.
Sternisha, SM, Liu P, Marshall AG, Miller BG Mechanistic origins of enzyme activation in human glucokinase variants associated with congenital hyperinsulinism. Biochemistry 2018, 57, 1632-1639.
Martinez, J.A., Xiao, Q., Zakarian, A., Miller, B.G. (2017) Antidiabetic disruptors of the glucokinase-glucokinase regulatory protein complex reorganize a coulombic interface. Biochemistry 2017, 56, 3150-3157.