Dr. Lei Zhu, Professor

Professional Preparation/Appointments

Ph.D. New York University (2003)

Contact Information

Email lzhu@chem.fsu.edu
Office 716 DLC 850.645.6813
Lab 755 DLC  

Programs of Research

Materials, Organic

Research Specialties

Bioanalytical, Chemical Biology, Synthesis and Catalysis, Spectroscopy and Photochemistry

Research Interest


The Zhu group is interested in solving fundamental problems in chemistry and developing new technologies using the tools in supramolecular chemistry – the chemistry mediated by rapidly equilibrating reactions. Metal coordination is one example of “rapidly equilibrating reactions” that we have invested much effort in studying. The acquired fundamental knowledge from out work aids the progress in other areas, including the development of fluorescent sensing technologies and new catalytic processes. Three current research topics are 1) developing fluorescent indicators for imaging biological Zn(II) ions, 2) photophysical investigation of interesting fluorescent molecules, and 3) developing copper-merdiated coupling reactions based on mechanistic hypotheses.


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Meisner, Q. J.; Younes, A. H.; Yuan, Z.; Sreenath, K.; Hurley, J. J. M.; Zhu, L. Excitation-Dependent Multiple Fluorescence of a Substituted 2-(2′-Hydroxyphenyl)benzoxazoleJ. Phys. Chem. A2018122, 9209-9223.
Macias-Contreras, M.; He, H.; Zhu, L. Beyond O6-benzylguanine: O6-(5-pyridylmethyl)guanine as a Substrate for the Self-labeling Enzyme SNAP-tagBioconjugate Chem201829, 4104-4109.
Brassard, C. J.; Zhang, X.; Brewer, C. R.; Liu, P.; Clark, R. J.; Zhu, L. Cu(II)-Catalyzed Oxidative Formation of 5,5’-BistriazolesJ. Org. Chem201681, 12091–12105.
Sreenath, K.; Yuan, Z.; Allen, J. R.; Davidson, M. W.; Zhu, L. A Fluorescent Indicator for Imaging Lysosomal Zinc(II) with FRET-Enhanced Photostability and A Narrow Band of EmissionChem. Eur. J. 201521, 867-874.
Kuang, G.-C.; Guha, P. M.; Brotherton, W. S.; Simmons, J. T.; Stankee, L. A.; Nguyen, B. T.; Clark, R. J.; Zhu, L. Experimental Investigation on the Mechanism of Chelation-Assisted, Copper(II) Acetate-Accelerated Azide-Alkyne CycloadditionJ. Am. Chem. Soc. 2011133, 13984-14001.