Dr. Qing-Xiang “Amy” Sang, Professor

Professional Preparation/Appointments

Endowed Professorship in Cancer Research
Ph.D. Georgetown University Medical Center (1990)

Contact Information

Email qxsang@chem.fsu.edu
Office 3007 CSL 850.644.8683
Lab 3501 CSL 850.644.4113

Programs of Research


research specialties

Bioanalytical, Chemical Biology, Structural Biology

Research Interest

​Dr. Sang’s laboratory deciphers the biochemical mechanisms of human breast, prostate, and brain cancer initiation, progression, metabolism, angiogenesis, and invasion for cancer biomarker and drug discovery. Protein biochemistry and genomics studies are combined with molecular cell biology, medicinal chemistry, biostatistics and bioinformatics, and biomedical engineering. Novel metalloproteinases such as human cancer-derived endometase/matrilysin-2 (MMP-26) and adamalysin 19 (ADAM19) were discovered. Pro-enzyme activation, substrate specificities, the inhibition kinetics, and the structure-function relationships of the proteinases and their inhibitors were investigated. The Sang group decoded the driven gene mutations and oncogenic pathways of brain cancer medulloblastoma. Human childhood brain malignant rhabdoid tumor is modeled using induced pluripotent stem cell-derived brain organoids. The gene editing and stem cell technologies are utilized to generate this novel cancer model for drug evaluation for the effective treatment of pediatric brain cancer. Environmental toxins are also evaluated using human cell lines and brain organoids.

Faculty Interview


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Timothy Hua, Yu Xue, Drishty B. Sarker, Sonia Kiran, Yan Li, Qing-Xiang Amy Sang, Modeling human brain rhabdoid tumor by inactivating tumor suppressor genes in induced pluripotent stem cells, Bioactive Materials, 31 (2024), 136-150, ISSN 2452-199X, https://doi.org/10.1016/j.bioactmat.2023.08.009. (https://www.sciencedirect.com/science/article/pii/S2452199X23002487)
Bou-Dargham MJ, Sha L, Sarker DB, Krakora-Compagno MZ, Chen Z, Zhang J, Sang QA. TCGA RNA-Seq and Tumor-Infiltrating Lymphocyte Imaging Data Reveal Cold Tumor Signatures of Invasive Ductal Carcinomas and Estrogen Receptor-Positive Human Breast Tumors. Int J Mol Sci. 2023 May 27;24(11). doi: 10.3390/ijms24119355. PubMed PMID: 37298307; PubMed Central PMCID: PMC10253224.
Jin Z, Dridi N, Palui G, Palomo V, Jokerst JV, Dawson PE, Amy Sang QX, Mattoussi H. Evaluating the Catalytic Efficiency of the Human Membrane-type 1 Matrix Metalloproteinase (MMP-14) Using AuNP-Peptide Conjugates. J Am Chem Soc. 2023 Mar 1;145(8):4570-4582. doi: 10.1021/jacs.2c12032. Epub 2023 Feb 20. PubMed PMID: 36802544.
Khamis ZI, Sarker DB, Xue Y, Al-Akkary N, James VD, Zeng C, Li Y, Sang QA. Modeling Human Brain Tumors and the Microenvironment Using Induced Pluripotent Stem Cells. Cancers (Basel). 2023 Feb 16;15(4). doi: 10.3390/cancers15041253. Review. PubMed PMID: 36831595; PubMed Central PMCID: PMC9954701.
Hu J, Van den Steen PE, Sang QX, Opdenakker G. Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases. Nat Rev Drug Discov. 2007 Jun;6(6):480-98. doi: 10.1038/nrd2308. Review. PubMed PMID: 17541420.