FLORIDA STATE / PEOPLE / FACULTY
Dr. Robert Silvers, Assistant Professor
B.S. Goethe University Frankfurt, Germany (2007)
M.S. Goethe University Frankfurt, Germany (2007)
Ph.D. Goethe University Frankfurt, Germany (2012)
Postdoc, Massachusetts Institute of Technology (2013-2018)
Programs of Research
Chemical Biology, Structural Biology
The Silvers laboratory is working to understand how proteins and RNA interact on a molecular level and how this interaction mediates function as well as dysfunction in diseases. In particular, our group is interested in the biogenesis of mitochondrial tRNA. The characterization of structure and dynamics of these ribonucleoproteins (RNPs) is achieved using state-of-the-art solution and solid-state NMR spectroscopy, besides other structural biological methods. Very few structures of RNPs involved in the biogenesis of mitochondrial tRNA have been obtained so far, however, the development of novel methods in solid-state NMR spectroscopy made it possible to study these important drug targets.
Click to View
Iadanza, M.G.*; Silvers, R*; Boardman, J.; Smith, H.I.; Karamanos, T.K.; Debelouchina, G.T.; Su, Y.; Griffin, R.G.; Ranson, N.A.; Radford, S.E.; The structure of a β2-microglobulin fibril suggests a molecular basis for amyloid polymorphism. Nature Communications 2018, 9, 4517.
Silvers, R.; Colvin, M.T.; Fredrick, K.K.; Jacavone, A.C.; Lindquist, S.L.; Linse, S.; Griffin, R.G. Aggregation and Fibril Structure of AβM01-42 and Aβ1-42. Biochemistry 2017, 56, 4850–4859.
Lehner, F.; Kudlinzki, D.; Richter, C.; Müller-Werkmeister, H.M.; Eberl, K.B.; Bredenbeck, J.; Schwalbe, H.; Silvers, R. Impact of Azidohomoalanine Incorporation on Protein Structure and Ligand Binding. ChemBioChem 2017, 18, 2340-2350.
Colvin, M.T.*; Silvers, R.*; Zhe, N.Q.; Can, T.V.; Sergeyev. I.; Rosay, M.; Donovan, K.J.; Michael, B.; Wall, J.; Linse, S.; Griffin, R.G. Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils. J. Am. Chem. Soc. 2016, 138, 9663–9674.
Colvin, M.T.*; Silvers, R.*; Frohm, B.; Su, Y.; Linse, S.; Griffin, R.G. High Resolution Structural Characterization of Aβ42 Amyloid Fibrils by MAS NMR. J. Am. Chem. Soc. 2015, 137, 7509-7518.