FLORIDA STATE / PEOPLE / FACULTY
Dr. Robert Silvers, Assistant Professor
B.S. Goethe University Frankfurt, Germany (2007)
M.S. Goethe University Frankfurt, Germany (2007)
Ph.D. Goethe University Frankfurt, Germany (2012)
Postdoc, Massachusetts Institute of Technology (2013-2018)
Programs of Research
Chemical Biology, Structural Biology
The Silvers laboratory is working to understand how proteins and RNA interact on a molecular level and how this interaction mediates function as well as dysfunction in diseases. In particular, our group is interested in the biogenesis of mitochondrial tRNA. The characterization of structure and dynamics of these ribonucleoproteins (RNPs) is achieved using state-of-the-art solution and solid-state NMR spectroscopy, besides other structural biological methods. Very few structures of RNPs involved in the biogenesis of mitochondrial tRNA have been obtained so far, however, the development of novel methods in solid-state NMR spectroscopy made it possible to study these important drug targets.
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Stefanovic, L.; Gordon, B.H.; Silvers, R.; Stefanovic, B. Characterization of sequence specific binding of LARP6 to the 5′ stem-loop of type I collagen mRNAs and implications for rational design of antifibrotic drugs. J. Mol. Biol. 2022, 434 (2), 167394.
Bahri, S.; Silvers, R.; Michael, B.; Jaudzems, K.; Lalli, D.; Casano, G.; Ouari, O.; Lesage, A.; Pintacuda, G.; Linse, S.; Griffin, R.G. 1H detection and dynamic nuclear polarization–enhanced NMR of Aβ1-42 fibrils. Proc. Natl. Acad. Sci. U.S.A. 2022, 119 (1), e2114413119.
Silvers, R.; Stephan, J.R.; Griffin, R.G.; Nolan, E.M. Molecular Basis of Ca(II)-Induced Tetramerization and Transition-Metal Sequestration in Human Calprotectin Journal Article. J. Am. Chem. Soc. 2021, 143 (43), 18073-18090.
Iadanza, M.G.; Silvers, R; Boardman, J.; Smith, H.I.; Karamanos, T.K.; Debelouchina, G.T.; Su, Y.; Griffin, R.G.; Ranson, N.A.; Radford, S.E. The structure of a β2-microglobulin fibril suggests a molecular basis for amyloid polymorphism. Nature Communications 2018, 9, 4517.
Colvin, M.T.; Silvers, R.; Zhe, N.Q.; Can, T.V.; Sergeyev. I.; Rosay, M.; Donovan, K.J.; Michael, B.; Wall, J.; Linse, S.; Griffin, R.G. Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils. J. Am. Chem. Soc. 2016, 138, 9663–9674.