Dr. Christian Bleiholder, Associate Professor

Professional Preparation/Appointments

M.Sc. University of Heidelberg (2004)
Ph.D. University of Heidelberg (2007)
Postdoc, University of California at Santa Barbara (2008-2013)

Contact Information

Email bleiholder@chem.fsu.edu
Office CSL 2001 850.645.4816

Programs of research

Analytical, Physical

research specialties

Bioanalytical, Computational Chemistry, Structural Biology

Research Interest

The Bleiholder group develops ion mobility spectrometry / mass spectrometry methods and applies these methods to investigate structure and dynamics of biological systems. We are developing both novel instrumentation, such as our tandem-trapped ion mobility spectrometer, as well as computational methods to accurately identify sequence and structure of protein systems from the recorded spectra. We are particularly interested in structure and dynamics of glycoproteins and their complex.


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C. Bleiholder, F. C. Liu Structure Relaxation Approximation (SRA) for Elucidation of Protein Structures from Ion Mobility Measurements. J. Phys. Chem. B 2019, 123, 2756-2769.
M. Chai, M. Young, F. C. Liu, C. Bleiholder A transferable, sample-independent calibration procedure for trapped ion mobility spectrometry (TIMS). Analytical Chemistry 2018, 90, 9040-9047.
.C. Liu, M. E. Ridgeway, M. A. Park, C. Bleiholder Tandem trapped ion mobility spectrometry.
Analyst 2018, 143, 2249-2258.
F.C. Liu, S. R. Kirk, C. Bleiholder On the Structural Denaturation of Biological Analytes in Trapped Ion Mobility Spectrometry – Mass Spectrometry. Analyst 2016, 141, 3722 – 3730.

C. Bleiholder A local collision probability approximation for predicting momentum transfer cross sections. Analyst 2015, 14, 6804-6813.